PH9241 | 顺铂（试剂级）Pt,65%&99.5% Cisplatin (Reagent grade) CAS号:15663-27-1

品名称 顺铂
英文名称 cis-Diammineplatinum dichloride
别名 Cisplatin；顺-二胺二氯铂(II)；顺-二氯二氨基铂(II)；顺式-二胺二氯铂;顺氯氨铂
英文别名 Cisplatin;cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; cis-Diammineplatinum(II) dichloride
CAS编号 15663-27-1
分子量 300.1
分子式 H6Cl2N2Pt
规格或纯度 Pt,65%&99.5%
运输条件 常温运输与避光保存，有效期3年


应用


cis-Diamineplatinum(II) dichloride can be used as a model drug to test the efficiency of various drug carriers in drug delivery.
cis-Diammineplatinum(II) dichloride has been used:
· in cell viability measurement in cochlear explants
· in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
· in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma


生化机理 Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G 2 /M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro .

微溶于水，易溶于二甲基甲酰胺。在水溶液中可逐渐转化成反式和水解。

溶解性 Soluble in DMSO (25 mg/ml), water (0.1-0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml)

注意：Cisplatin在溶液中很不稳定，使用时尽量新鲜配制。Cisplatin常见使用浓度范围为1-100μM。具体的最佳工作浓度请参考相关文献。


*本品仅供科研实验使用，为试剂级别，不能用于治疗和诊断使用，购买时请注意！